منابع مشابه
Dock and Pak regulate olfactory axon pathfinding in Drosophila.
The convergence of olfactory axons expressing particular odorant receptor (Or) genes on spatially invariant glomeruli in the brain is one of the most dramatic examples of precise axon targeting in developmental neurobiology. The cellular and molecular mechanisms by which olfactory axons pathfind to their targets are poorly understood. We report here that the SH2/SH3 adapter Dock and the serine/...
متن کاملIs Required for Axon Pathfinding by Olfactory Sensory Neurons
Timothy R. Henion,1,2 Denitza Raitcheva,1 Robert Grosholz,1 Franziska Biellmann,3 William C. Skarnes,4 Thierry Hennet,3 and Gerald A. Schwarting1,2 1Shriver Center, Waltham, Massachusetts 02452, 2Department of Cell Biology, University of Massachusetts Medical Center, Worcester, Massachusetts 01655, 3Institute of Physiology, University of Zurich, CH-8057 Zurich, Switzerland, and 4Wellcome Trust ...
متن کاملFollow Your Nose: Axon Pathfinding in Olfactory Map Formation
Two new studies report how discrete identities of olfactory sensory neurons are converted into a spatial map of axonal connections (Imai et al., 2006; Serizawa et al., 2006). They find that levels of cAMP signals derived from olfactory receptors (ORs) can direct targeting of axons along an axis, and that ORs and neural activity regulate expression of adhesion/guidance molecules in mosaic patter...
متن کاملOlfactory Axon Pathfinding Who Is the Pied Piper?
Mammalian olfactory sensory neurons that express a particular odorant receptor (OR) project axons to the same few glomeruli in the olfactory bulb. In this issue of Neuron, Vassalli et al. use OR minigenes that coexpress histochemical markers and show that the determinants in the sensory neurons required to generate the stereotyped olfactory bulb map are the same as those needed for appropriate ...
متن کاملTranscriptional Regulation of Axon Pathfinding
different species and neuron types. Some are candi-† Neuron dates for being direct regulators of the molecules that Cell Press confer pathfinding specificity. In each system dis-Cambridge, Massachusetts 02138 cussed, the projection phenotypes of the neurons involved had been described previously so that alterations in pathfinding were easily recognized. Neuronal differentiation has been postula...
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ژورنال
عنوان ژورنال: Neuron
سال: 2002
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(02)00831-0